Cromolyn Sodium for Insulin-Induced Lipoatrophy: Old Drug, New Use
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چکیده
منابع مشابه
Cromolyn Sodium for Insulin-Induced Lipoatrophy: Old Drug, New Use
Local insulin-induced lipoatrophy, an immune-mediated loss of subcutaneous adipose tissue at insulin administration sites, is now a rare complication of insulin therapy in patients with diabetes. Lipoatrophy incidence, previously noted in 10–55% of patients using animal-derived insulins (1), declined considerably with the advent of and improved purity of modern insulins. Yet, it continues to be...
متن کاملHuman insulin analog--induced lipoatrophy.
OBJECTIVE To characterize the pathophysiology of recombinant human insulin-induced lipoatrophy. RESEARCH DESIGN AND METHODS We performed immunologic laboratory evaluation and skin testing for different insulin analogs and diluents in patients with type 1 diabetes and severe insulin-induced local lipoatrophy. Subcutaneous adipose tissue biopsies of areas of acute (7 days) and chronic insulin a...
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A 46-year-old Japanese woman with type 2 diabetes noticed a depression in her right anterior abdomen where she had previously injected insulin for approximately 9months (humanneutral protamine Hagedorn insulin and insulin lispro), and this lesion expanded to her right groin. About 18 months after the insulin injections were stopped, a second depression lesion appearedonher left buttockwhere she...
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Skin biopsy samples from 14 diabetic patients with lipoatrophy at injection sites and from five insulin-treated diabetic patients without such lipoatrophy (controls) were examined by immunofluorescence for the deposition of immunological components. Also sera from 13 of the patients with lipoatrophy and from all of the controls were assayed for insulin-binding capacity. Biopsy samples from the ...
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Corresponding author: Young-Tae Jeon, M.D., Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam 463-802, Korea. Tel: 82-31-787-7499, Fax: 82-31-787-4063, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommon...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2013
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc13-1123